Objective To analyze the clinical characteristics of Fuchs' heterochromic iridocyclitis and discuss clinical therapy methods.Methods It was a retrospective case-series study.Patients with histories of hypertension,diabetes,injury,or steroid use were excluded since these conditions can cause other diseases of the eye.One hundred and four eyes of 101 patients who were diagnosed with Fuchs' heterochromic iridocyclitis between April 1994 and November 2010 were included in the study.The patients were divided into six groups according to their age:20-30 years old,31-40 years old,41-50 years old,51-60 years old,61-70 years old,71-78 years old.Statistical data included age,gender,course of disease,clinical presentations,complications,and follow-up visual acuity and intraocular pressure examinations after surgery.SPSS 17.0 was used to analyze preoperative intraocular pressure and visual acuity comparing with postoperative by Wilcoxon matched pairs signed-ranks test,corneal endothelial cell number,sexangular cell ratio and coefficient of variation comparing with normal by independent samples rank test.Results Three of 101 patients were bilateral (3.0％); there was no difference in OCcurrence sides (x2=10.628,P＞0.05).The ratio of males versus females was 1.2:1,and was not statistically significant (x2=9.31,P＞0.05).The percentage of patients who presented with different clinical manifestations were as follows:reduced visual acuity (100.0％),pigmented keratic precipitates (25.0％),mutton fat keratic precipitates (75.0％),iris atrophy (56.7％),heterochromia (24.0％),vitreous opacification (100.0％),cataract (98.1％) and glaucoma (16.3％).Comeal endothelial cell number (Z=-1.601,P＞0.05),sexangular cell ratio (Z=-0.961,P＞0.05) and coefficient of variation (Z=-0.321,P＞0.05) were insignificant compare with normal.Visual acuity improved significantly after cataract extraction with intraocular lens inplantation (Z=-2.201,P＜0.05),anti-glaucoma surgery was performed to maintain normal intraocular pressure (Z=-2.201,P＜0.05).Secondary glaucoma occurred in 3 of 6 patients after cataract extraction surgery during the regular one-year follow-up period; 4 patients who underwent anti-glaucoma surgery had normal intraocular pressure during the regular follow-up period.Conclusion Fuchs' heterochromic iridocyclitis is characterized by reduced visual acuity,pigmented or mutton fat keratic precipitates,iris atrophy and depigmentation,even heterochromia,mild inflammation of the anterior chamber and vitreous,and an increased incidence of heterochromia over an extended period.Corneal endothelial cells,sexangular cell ratio and the coefficient of variation were normal.Patients underwent cataract extraction and anti-glaucoma surgery need regular follow-up to maintain intraocular pressure and vision.