Objective To study the changes in contrast sensitivity and glare sensitivity after intensive glucose control during a six-month follow-up period.Methods In a prospective case series study,108 eyes of 54 patients who underwent intensive glucose control treatment were included in this study.The Takagi CGT-1000 was used to obtain contrast sensitivity and glare sensitivity for the eyes of all patients.Measurements were taken at pre-treatment,3 and 6 months after intensive glucose control.The repeat measurement ANOVA and the least-significant difference (LSD) pairwise were used for statistical comparison and data analysis.Results Contrast sensitivity:contrast sensitivities at 6.3°,2.5°,1.6° and 1.0° 3 months after intensive glucose control were higher than those before treatment (t=2.521,3.298,2.808,3.275,P＜0.05); contrast sensitivities at 2.5° and 1.0° 6 months after intensive glucose control were higher than those before treatment (t=2.096,2.059,P＜0.05).There was no significant difference in contrast sensitivity at each frequency between 3 months and 6 months.Glare sensitivity:Glare sensitivities at low,moderate and high frequencies 3 months and 6 months after intensive glucose control were higher than those before treatment.However,there was no statistically significant difference at each frequency between the pre-treatment and post-treatments (F ranged from 1.092 to 3.046,P＞0.05).Conclusion Intensive glucose control can improve visual function for the short term and may delay the progress of visual function damage in the early stage of diabetic retinopathy.