Advances in Pathological Diagnosis of IgG4-Related Ophthalmic Disease
Xiaoyi Qin1 , Jinyong Lin2 , Shunhai Yang3
1 Department of Pathology, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China 2 Department of Pathology, Tianjin Eye Hospital, Tianjin 300020, China 3 Department of Ophthalmology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
IgG4-related ophthalmic diseases (IgG4-ROD) are IgG4-related diseases (IgG4-RD) occurring in the ophthalmic region, and the lacrimal gland is the most common site of ocular involvement. Intraocular and scleritis involvement in IgG4-ROD have recently been a hot topic. The etiology, clinical characteristics, laboratory examination, diagnosis and differential diagnosis of IgG4-ROD are reviewed in this paper.
Desphande V, Zen Y, Chan J, et al. Consensus statement on the pathology of IgG4-related disease. Modern Pathol, 2012, 25(9): 1181-1192. DOI: 10.1038/modpathol.2012.72.
[2]
Ebbo M, Patient M, Grados A, et al. Ophthalmic manifestations in IgG4-related disease: Clinical presentation and response to treatment in a French case series. Medicine (Baltimore), 2017,96(10): e6205. DOI: 10.1097/MD.0000000000006205.
Reynolds GL, Norris JH, Aslam S, et al. IgG4-related disease presenting as posterior scleritis and vitritis, progressing to multifocal orbital involvement. BMJ Case Rep, 2017, 23: 2017. DOI: 10.1136/bcr-2017-219568.
[5]
Nastri MMF, Novak GV, Sallum AEM, et al. Immunoglobulin G4-related disease with recurrent uveitis and kidney tumor mimicking childhood polyarteritis nodosa: A rare case report. Acta Reumatol Port, 2018, 43(3): 226-229.
[6]
Sato Y, Ohshima K, Ichimura K, et al. Ocular adnexal IgG4-related disease has uniform clinicopathology. Pathol Int, 2008, 58(8): 465-70. DOI: 10.1111/j.1440-1827.2008.02257.x.
[7]
Kim N, Yang HK, Kim JH, et al. IgG4-related ophthalmic disease involving extraocular muscles: Case series. BMC Ophthalmol, 2018, 18(1): 162. DOI: 10.1186/s12886-018-0819-x.
[8]
Suzuki M, Mizumachi T, Morita S, et al. A case of immunoglobulin 4-related disease with bilateral mass-forming lesions in the nasolacrimal ducts. J Clin Rheumatol, 2011, 7(4): 207-210. DOI: 10.1097/RHU.0b013e31821c71a3.
[9]
Watanabe T, Yamashita K, Kudo M. IgG4-related disease and innate immunity. Curr Top Microbiol Immunol, 2017, 401: 115-128. DOI: 10.1007/82_2016_42.
[10]
Ota M, Umemura T, Kawa S. Immunogenetics of IgG4-related AIP. Curr Top Microbiol Immunol, 2017, 401: 35-44. DOI: 10.1007/82_2016_37.
[11]
Yamamoto M, Takano KI, Kamekura R, et al. Analysis of allergic reaction in IgG4-related disease. Mod Rheumatol, 2019, 24: 1-3. DOI: 10.1080/14397595.2019.1572488.
[12]
Aihara Y, Azumi A, Furuta M, et al. Japanese study group of IgG4-related ophthalmic disease. A prevalence study of IgG4-related ophthalmic disease in Japan. Jpn J Ophthalmol, 2013, 57(6): 573-579. DOI: 10.1007/s10384-013-0266-4.
[13]
Marie Takeishi, Toshiyuki Oshitari, Satomi Ota, et al. The case of IgG4-related ophthalmic disease accompanied by compressive optic neuropathy. Neuroophthalmology, 2018, 42(4): 246-250. DOI: 10.1080/01658107.2017.1389962.
[14]
Li A, Plesec TP, Mileti L, et al. Isolated conjunctival inflammation as a manifestation of IgG4-related disease. Cornea, 2018, 37(9): 1182-1184. DOI: 10.1097/ICO.0000000000001638.
[15]
Soussan JB, Deschamps R, Sadik JC, et al. Infraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: A specific sign. Eur Radiol, 2017, 27(4): 1335-1343. DOI: 10.1007/s00330-016-
44
81-5.
[16]
Umehara H, Okazaki K, Masaki Y, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol, 2012, 22(1): 21-30. DOI: 10.1007/s10165-011-0571-z.
[17]
Goto H, Takahira M, Azumi A. Diagnostic criteria for IgG4-related ophthalmic disease. Jpn J Ophthalmol, 2015, 59(1):1-7. DOI: 10.1007/s10384-014-0352-2.
[18]
Ebbo, M, Grados, A, Guedj, E, et al. Usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography for staging and evaluation of treatment response in IgG4-related disease: A retrospective multicenter study. Arthritis Care Res (Hoboken), 2014, 66: 86-96. DOI: 10.1002/acr.22058.
[19]
Ishii S, Shishido F, Miyajima M, et al. Whole-body gallium-67 scintigraphic findings in IgG4-related disease. Clin Nucl Med, 2011, 36(7): 542-545. DOI: 10.1097/RLU.0b013e318217ae16.
[20]
Sato Y, Takata K, Ichimura K, et al. IgG4-producing marginal zone B-cell lymphoma. Int J Hematol, 2008, 88(4): 428-433. DOI: 10.1007/s12185-008-0170-8.
[21]
Yamamoto M, Takahashi H, Ohara M, et al. A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol, 2006, 16(6): 335-340. DOI: 10.1007/s10165-006-0518-Y.