Objective An aspheric intraocular lens (IOL) with fixed spherical aberration (SA) implanted in an individual patient will not always obtain ideal optical quality since human corneal structure and SA have large individual variations.The aim of this research was to study optical performance of individual pseudophakic eye models that were constructed based on individual anatomic parameters and implanted IOL with different optical designs.Methods Computer numerical simulation experiment.The anatomic parameters of individual pseudophakic patients were obtained by Pentacam and IOL Master.Parameters were input into ZEMAX to build individual eye models.Three aspheric IOL (SofPort AO,Tecnis Z9000,FY60AD) and one spherical IOL (YA60BBR) were implanted into individual eye models.Modulation transfer function (MTF) and contrast sensitivity function (CSF) were calculated for 3 mm to 5 mm pupil diameters and 550 nm wavelength.Results The height of the MTF and CSF curves were decreased with larger pupils.They were similar with the 4 IOL implanted in the individual eye models for 3 mm pupil diameter,but they were different from each other for 4 and 5 mm pupils,indicating that individual people with different anatomic structures need certain types of IOL to obtain optimal optical performance.This phenomenon was more pronounced for larger pupil.Conclusion The individual eye model based on an individual patient's anatomic parameters should mimic the optical performance of an individual's eye.The type of IOL is varied to obtain optimal optical performance for the optical system of the human eye with different anatomic structures.We should choose an IOL based on the individual eye's structure to obtain optimal retinal image clinically.