Objective To evaluate the longitudinal development of electroretinographic （ERG） sensitivity in normal SD rats. Methods In an experimental study， scotopic ERGs of 22 eyes of 22 rats were recorded postnatally （P） on P16， P18， P30±2 and P64±2 days. The stimulus light was white with gradient intensities. Rod sensitivity （S） and the saturated a wave （Rmp3） were obtained by fitting Hood′s function. Sensitivity of the b wave （σ） and maximum b wave （Vmax） were calculated by regression using the Naka-Rushton function. ANOVA was used to test the differences in ERG parameters at different postnatal ages. Results Both rod sensitivity （S） and b wave sensitivity （σ） increased with development. The highest Rmp3 was obtained at P18 while Vmax occurred at P30±2 days. Conclusion Alteration of rod sensitivity increased with postnatal development and reflected the developmental characteristics of rod function of SD rat.
刘克高,彭晓燕,陈凤华,孙华. 正常SD大鼠视网膜电图敏感度功能的发育[J]. 中华眼视光学与视觉科学杂志, 2013, 15(6): 332-335.
LIU Ke-gao,PENG Xiao-yan,CHEN Feng-hua,SUN Hua. Functional development changes in electroretinographic sensitivity in the normal SD rats. Chinese Journal of Optometry Ophthalmology and Visual Science, 2013, 15(6): 332-335. DOI: 10.3760/cma.j.issn.1674-845X.2013.06.004
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