Objective To investigate the changes in ocular wavefront aberrations that were induced by physiological accommodation. Methods A descriptive study was adopted for this research and the different stages of ocular accommodation were induced by moving the visual target. At the same time， the value of wavefront aberrations was measured under different accommodative stages. These results were used to evaluate the induced amplitude and to compare the differences in higher-order aberrations for the groups with accommodative amplitudes greater than 3 D and less than 3 D under a relaxed state. In addition， the characteristic changes in wavefront aberrations for three different levels of accommodative demand （0 D， 1 D， 3 D） and between pupil diameters at 3.11 mm and 4.93 mm were evaluated and compared. The collected data was analyzed by independent t tests and an ANOVA. Results The induced accommodation was achieved under the present experimental conditions with a maximum amplitude up to 7.43 D. There was no statistical difference between the groups with amplitudes greater than or less than 3 D in terms of higher-order aberrations. With accommodation between the 0 D and 3 D range， the change in higher-order aberrations was not statistically significant. However， during the process of accommodation， the values of coefficients 12， 24 and 33 from the Zernike polynomial pyramid， which were all located on the axial of the pyramid， had statistically significant changes （Mini F=3.799， P<0.05）. Conclusion When the human eye is in the accommodative mode， there are structural changes in higher order aberrations that compensate for the change in defocus.